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Biosciences and Biotechnology
Researchers Set to Decode Biological Circuitry That Drives Peak Performance and Resilience
DARPA’s Measuring Biological Aptitude (MBA) program begins and ends with the men and women of the United States military. The program — first announced in January 2019 — centers on how service members can access the potential of their own biological systems to achieve peak results across a range of military specializations, and aims for a detailed understanding of how…
Understanding effects of tissue-specific extracellular matrix molecules on brain cells
In vitro organ-on-a-chip experimental platforms hold great promise to predict human biology and human-relevant responses to chemical and biological stimuli. LLNL scientists and engineers are working to more faithfully recapitulate the brain microenvironment on multi-electrode arrays to study brain activity. In an article recently published in Scientific Reports, Livermore…
Designing sensors for environmental uranium detection
The ability to detect uranium (U) through environmental monitoring is of critical importance for informing water resource protection and nonproliferation efforts. While technologies exist for environmental U detection, wide-area environmental monitoring—sampling coverage over large areas not known to possess U contamination—remains a challenging prospect that necessitates…
Barrier membrane demonstrates biosensing platform protection
Biological signaling mechanisms often involve small molecules, ions, and protons, and facile in situ monitoring of the levels of these species is vital for medical diagnostics. Even the simplest signals, such as intracellular pH level, can provide important information. Of all biosensing platforms, electrical sensors represent the best opportunity to develop implantable…
Computational and Experimental Models Combine in Science on Saturday Program
LLNL scientists Nick Be (left) and Tim Carpenter describe the computational (in silico) methods and experimental (in vitro and in vivo) techniques used to speed up the therapeutic drug optimization process. The combination of these methods creates a pipeline to help scientists test more therapeutics at a lower cost. (Photo by Joanna Albala/LLNL Science Education Program.)…
Using nanoSIMS to study virus structure
Because of their size, lack of symmetry, structural heterogeneity, and high molecular weight, most large animal and human viruses are not amenable to typical analytical techniques, such as x-ray crystallography, nuclear magnetic resonance analyses, or fine-scale reconstruction by cryo-electron microscopy. In a recently published paper in Analytical Chemistry, NACS and BBTD…
Optimizing nanoparticles for in vivo applications
For several years, Lawrence Livermore has been developing a novel class of nanoparticles for biomedical applications that are highly biocompatible and offer advantages that other nanoparticle types do not. These nanoparticles, termed nanolipoprotein particles (NLPs), consist of a phospholipid bilayer stabilized by an apolipoprotein scaffold protein and are lab-made…
Antimicrobial resistance on the International Space Station
In an effort to minimize antimicrobial resistance (AMR) threat to astronauts, who may be immunocompromised and thus at a greater risk of infection from pathogens, a comprehensive study of the International Space Station “resistome” was conducted by a team of scientists from the Jet Propulsion Laboratory, LLNL, the Naval Medical Research Center, and AlloSource. Using a…
Biomedical Technology Accelerates into ‘Science on Saturday’ Program
Lawrence Livermore National Laboratory’s (LLNL’s) educational outreach program Science on Saturday returned in February for a season of Marvelous Machines. Held annually at the Bankhead Theater in downtown Livermore, the lecture series offers local students and the public a peek into LLNL’s recent research. In a February 10 presentation titled “Biomedical Accelerator Mass…
‘Science on Saturday’ lecture combines biomedical and computational power to decode rabies
On February 11, hundreds filled the Bankhead Theater in downtown Livermore for a presentation titled “Reconstructing a Rabies Epidemic: Byte by Byte.” As part of Lawrence Livermore National Laboratory’s (LLNL’s) educational outreach program Science on Saturday, the interactive lecture featured biomedical scientist Monica Borucki, bioinformatics scientist Jonathan Allen,…
